DaunorubicinisananthracyclinefirstproducedbyStreptomyces.Daunorubicinexhibitsanticancerchemotherapeuticactivityandisclinicallyusedtotreatvariouscancers,includingneuroblastomaandacutemyelogenousleukemia(AML).Likeotheranthracyclines,daunorubicinactsasanintercalatorandinhibitoroftopoisomeraseII.DaunorubicinalsopromoteshistoneH2AXevictionfromchromatin,inhibitingDNArepairmechanisms.
| CasNo. | 23541-50-6 |
|---|---|
| Purity | ≥98% |
| Formula | C27H29NO10•HCl |
| FormulaWt. | 564.0 |
| ChemicalName | (8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione |
| IUPACName | (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride |
| Synonym | Daunomycin;LeukaemomycinC;Rubidomycin;RP-13057;Cerubidin. |
| MeltingPoint | 188-190°C(dec.) |
| Solubility | Solubleinwaterorethanol. |
| Appearance | Orange-redCrystallinePowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | D0182MSDSPDF |
|---|---|
| InfoSheet | D0182InfoSheetPDF |
PangB,QiaoX,JanssenL,etal.Drug-inducedhistoneevictionfromopenchromatincontributestothechemotherapeuticeffectsofdoxorubicin.NatCommun.2013;4:1908.PMID:23715267.
QuigleyGJ,WangAH,UghettoG,etal.Molecularstructureofananticancerdrug-DNAcomplex:daunomycinplusd(CpGpTpApCpG).ProcNatlAcadSciUSA.1980Dec;77(12):7204-8.PMID:6938965.
