ThiscompoundistheEstereoisomerofJIB-04,aninhibitorofJumonjifamilyhistonedemethylases;itdoesnotinhibitactivityofα-ketoglutarate.JIB-04exhibitsanticancerchemotherapeuticactivity,inhibitingproteintranslationinitiation.Incancermodels,JIB-04inhibitscellviABIlity,decreasestumorburden,andincreasessurvivalrates.
| CasNo. | 199596-05-9 |
|---|---|
| Purity | ≥98% |
| Formula | C17H13ClN4 |
| FormulaWt. | 308.77 |
| ChemicalName | (E)-N-(5-Chloro-pyridin-2-yl)-N′-(phenyl-pyridin-2-yl-methylene)-hydrazine |
| IUPACName | 5-Chloro-2-{(2E)-2-[phenyl(2-pyridinyl)methylene]hydrazino}pyridine |
| Synonym | NSC693627,JHDMinhibitorVII |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | J3204InfoSheetPDF |
|---|
VanRechemC,BlackJC,BoukhaliM,etal.LysinedemethylaseKDM4Aassociateswithtranslationmachineryandregulatesproteinsynthesis.CancerDiscov.2015Mar;5(3):255-63.PMID:25564516.
WangL,ChangJ,VargheseD,etal.AsmallmoleculemodulatesJumonjihistonedemethylaseactivityandselectivelyinhibitscancergrowth.NatCommun.2013;4:2035.Erratumin:NatCommun.2013;4:2639.PMID:23792809.
