NVP-BHG712isanorallyactiveselectiveinhibitorofEphB4,whichplaysasignificantroleinvesseldevelopment,vasculardevelopment,andtumorangiogenesis.Thiscompoundexhibitsanticancerchemotherapeuticandanti-angiogenicactivity,inhibitingEphB4autophosphorylationandVEGF-inducedangiogenesis.
| CasNo. | 940310-85-0 |
|---|---|
| Purity | ≥98% |
| Formula | C26H20F3N7O |
| FormulaWt. | 503.48 |
| ChemicalName | 4-methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide- |
| IUPACName | 4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide |
| Solubility | DMSO101mg/mL |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | N8460InfoSheetPDF |
|---|
WnukM,HlushchukR,JanotM,etal.PodocyteEphB4signalinghelpsrecoveryfromglomerularinjury.KidneyInt.2012Jun;81(12):1212-25.PMID:22398409.
Martiny-BaronG,HolzerP,BillyE,etal.ThesmallmoleculespecificEphB4kinaseinhibitorNVP-BHG712inhibitsVEGFdrivenangiogenesis.Angiogenesis.2010Sep;13(3):259-67.PMID:20803239.
