OrlistatisaninhibitoroffattyacidsynthasethatisclinicallyadmiNISTeredforitsanti-obesitybenefits.Orlistatisoftenusedasaweightlossaid,althoughitalsoexhibitsanticancerchemotherapeuticactivity.InanimalmodelsofTcelllymphoma,orlistatincreaseslevelsofROS,NO,caspase3,Bcl-2,andp53,increasinglifespanandinhibitingtumorgrowth;similarresultsarefoundinanimalmodelsofcolorectalcarcinoma.
| CasNo. | 96829-58-2 |
|---|---|
| Purity | ≥98% |
| Formula | C29H53NO5 |
| FormulaWt. | 495.73 |
| ChemicalName | N-Formyl-L-leucine(1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]-dodecylester |
| IUPACName | (2S)-1-[(2S,3S)-3-Hexyl-4-oxo-2-oxetanyl]-2-tridecanylN-formyl-L-leucinate |
| Synonym | Orlipastat;Xenical |
| MeltingPoint | 43°C |
| Solubility | SolubleinDMSOorethanol. |
| Appearance | Off-whitewaxypowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | O6845InfoSheetPDF |
|---|
KantS,KumarA,SinghSM.TumorgrowthretardationandchemosensitizingactionoffattyacidsynthaseinhibitororlistatonTcelllymphoma:implicationofreconstitutedtumormicroenvironmentandmultidrugresistancephenotype.BiochimBiophysActa.2014Jan;1840(1):294-302.PMID:24060750.
ChuangHY,ChangYF,HwangJJ.Antitumoreffectoforlistat,afattyacidsynthaseinhibitor,isviaactivationofcaspase-3onhumancolorectalcarcinoma-bearinganimal.BiomedPharmacother.2011Jul;65(4):286-92.PMID:21723078.
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