OSI-027isaninhibitorofmTORC1/2thatexhibitsanticancerchemotherapeuticactivity.Invitro,OSI0027inhibitsphosphorylationofdownstreamtargetAkt,inhibitingcellproliferationinbreastcancercells.OSI-027alsoinducesapoptosisinseverallymphoidcelllinesincludingmantlecelllymphoma,acutelymphocyticleukemia(ALL),andothers.Inanimalmodelsofcancer,thiscompoundinhibitstumorgrowth.
| CasNo. | 936890-98-1 |
|---|---|
| Purity | ≥98% |
| Formula | C21H22N6O3 |
| FormulaWt. | 406.44 |
| IUPACName | 4-[(5Z)-4-amino-5-(7-methoxyindol-2-ylidene)-1H-imidazo[5,1-f][1,2,4]triazin-7-yl]cyclohexane-1-carboxylicacid |
| Appearance | Paleyellowpowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | O7332InfoSheetPDF |
|---|---|
| Brochures | PI3K-Akt-mTORCPathwayBooklet |
LiH,LinJ,WangX,etal.TargetingofmTORC2preventscellmigrationandpromotesapoptosisinbreastcancer.BreastCancerResTreat.2012Aug;134(3):1057-66.PMID:22476852.
GuptaM,HendricksonAE,YunSS,etal.DualmTORC1/mTORC2inhibitiondiminishesAktactivationandinducesPuma-dependentapoptosisinlymphoidmalignancies.Blood.2012Jan12;119(2):476-87.PMID:22080480.
FalconBL,BarrS,GokhalePC,etal.ReducedVEGFproduction,angiogenesis,andvascularregrowthcontributetotheantitumorpropertiesofdualmTORC1/mTORC2inhibitors.CancerRes.2011Mar1;71(5):1573-83.PMID:21363918.
VakanaE,SassanoA,PlataniasLC.InductionofautophagybydualmTORC1-mTORC2inhibitioninBCR-ABL-expressingleukemiccells.Autophagy.2010Oct;6(7):966-7.PMID:20699667.
