Description
Nedaplatinisasecondgenerationplatinumcompoundthatexhibitsanticancerchemotherapeuticactivity.NedaplatinisaDNAcross-linkingagentthatactsbybindingtheN7positiononguanineresidues,inhibitingDNAsynthesisandrepair.
Nedaplatinisasecondgenerationplatinumcompoundthatexhibitsanticancerchemotherapeuticactivity.NedaplatinisaDNAcross-linkingagentthatactsbybindingtheN7positiononguanineresidues,inhibitingDNAsynthesisandrepair.
| CasNo. | 95734-82-0 |
|---|---|
| Purity | ≥98% |
| Formula | C2H8N2O3Pt |
| FormulaWt. | 303.18 |
| IUPACName | azanide;2-hydroxyaceticacid;platinum(2+) |
| MeltingPoint | 130°C |
| Appearance | Offwhitetopaleyellowgreenpowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | N0212MSDSPDF |
|---|---|
| InfoSheet | N0212InfoSheetPDF |
YuanG,WuL,HuangM,etal.AphaseIIstudyofconcurrentchemo-rADIotherapywithweeklynedaplatininadvancedsquamouscellcarcinomaoftheuterinecervix.RadiatOncol.2014Feb18;9:55.PMID:24533532.
AliI,WaniWA,SaleemK,etal.Platinumcompounds:ahopeforfuturecancerchemotherapy.AnticancerAgentsMedChem.2013Feb;13(2):296-306.PMID:22583420.
PoklarN,PilchDS,LippardSJ,etal.Influenceofcisplatinintrastrandcrosslinkingontheconformation,thermalstABIlity,andenergeticsofa20-merDNAduplex.ProcNatlAcadSciUSA.1996Jul23;93(15):7606-11.PMID:8755522.