NMS-873 inhibits valosin-containing protein (VCP; p97/Cdc48p), an ATPase involved in endoplasmic reticulum-associated degradation. NMS-873 displays anticancer activity, activating the unfolded protein response, interfering with autophagy, and inducing cell death in cancer cells.
| Cas No. | 1418013-75-8 |
|---|---|
| Purity | ≥98% |
| Formula | C27H28N4O3S2 |
| Formula Wt. | 520.67 |
| IUPAC Name | 3-[3-(Cyclopentylsulfanyl)-5-({[2-methyl-4'-(methylsulfonyl)-4-biphenylyl]oxy}methyl)-4H-1,2,4-triazol-4-yl]pyridine |
| Synonym | NMS873 |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | N4972 Info Sheet PDF |
|---|
Chou TF, Bulfer SL, Weihl CC, et al. Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains. J Mol Biol. 2014 Jul 29;426(15):2886-99. PMID: 24878061.
Magnaghi P, D'Alessio R, Valsasina B, et al. Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013 Sep;9(9):548-56. PMID: 23892893.
