NVP-AUY922isanisoxazole-basedinhibitorofheatshockprotein90(HSP90)thatdisplaysanticancerchemotherapeuticandanti-angiogenicactivities.NVP-AUY922inhibitscellgrowthinpancreaticandcolorectalcancercells.InadultT-cellleukemiacells,NVP-AUY922inducesG1phasecellcyclearrestandapoptosis,suppressingcellgrowth.Additionally,thiscompoundinducestumorregressionanddecreasesmicrovesseldensityinanimalmodelsofbreastcancer,ovariancancer,prostatecancer,andmelanoma.
| CasNo. | 747412-49-3 |
|---|---|
| Purity | ≥98% |
| Formula | C26H31N3O5 |
| FormulaWt. | 465.54 |
| IUPACName | 5-(2,4-Dihydroxy-5-isopropylphenyl)-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-1,2-oxazole-3-carboxamide |
| Synonym | VER-52296 |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | N8660InfoSheetPDF |
|---|
KimSH,KangJG,KimCS,etal.NovelHeatShockProtein90InhibitorNVP-AUY922SynergizesWiththeHistoneDeacetylaseInhibitorPXD101inInductionofDeathofAnaplasticThyroidCarcinomaCells.JClinEndocrinolMetab.2015Feb;100(2):E253-61.PMID:25389633.
TaniguchiH,HasegawaH,SasakiD,etal.Heatshockprotein90inhibitorNVP-AUY922exertspotentactivityagainstadultT-cellleukemia-lymphomacells.CancerSci.2014Dec;105(12):1601-8.PMID:25263741.
EcclesSA,MasseyA,RaynaudFI,etal.NVP-AUY922:anovelheatshockprotein90inhibitoractiveagainstxenografttumorgrowth,angiogenesis,andmetastasis.CancerRes.2008Apr15;68(8):2850-60.PMID:18413753.
