Description
GNF-2isaninhibitorofAblkinasethatexhibitsanticancerchemotherapeutic,anti-resorptive,andanti-osteoporoticactivities.GNF-2showspotentialbenefitinthetreatmentofPhiladelphiachromosome-positiveacutemyelogenousleukemia(ALL).Invitro,GNF-2inhibitsdifferentiationofosteoclasts,activityofNF-κB,andinductionofc-FosandNFATc1,resultingincaspase-mediatedapoptosis.GNF-2alsoinhibitsresorptionofmatureosteoclastsandpreventsphagocytosisinbonemarrow-derivedmacrophages.Invivo,thiscompounddecreasesosteoclastnumbersandpreventsboneloss.
References
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