LevocetirizineistheL-isomerofcetirizine,asecond-generationhistamineH1receptorantagoNIST.Levocetirizineexhibitsanti-allergic,anti-inflammatory,andimmunomodulatoryactivities.Inanimalmodelsofallergicconjunctivitis,levocetirizinedecreaseslevelsoflipoxinA4,TNF-α,TGF-β,andantigenpresentingcells(APCs)andincreaseslevelsofIL-10.Additionally,thiscompoundincreaseslevelsofCD4+CD25+Tcellsanddecreaseslevelsofeosinophils,decreasingallergysymptomsinclinicalsettings.
| CasNo. | 130018-87-0 |
|---|---|
| Purity | ≥98% |
| Formula | C21H25ClN2O3•2HCl |
| FormulaWt. | 461.81 |
| ChemicalName | Aceticacid,(2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-hydrochloride |
| IUPACName | 2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]aceticacid;dihydrochloride |
| Synonym | (−)-Cetirizine;Xusal;Xyzal |
| MeltingPoint | 215-220°C |
| Appearance | Whitetooff-whitecrystallinepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | L1780MSDSPDF |
|---|---|
| InfoSheet | L1780InfoSheetPDF |
García-ZepedaS,Estrada-MuñizE,ElizondoG,etal.LevocetirizineinhibitsmigrationofimmunecellstolymphnodesandinducestregcellsinamurinetypeIallergicconjunctivitismodel.OpenOphthalmolJ.2012;6:129-36.PMID:23284599.
MahmoudF,ArifhodzicN,HainesD,etal.Levocetirizinemodulateslymphocyteactivationinpatientswithallergicrhinitis.JPharmacolSci.2008Oct;108(2):149-56.PMID:18946193.
