Levonorgestrelisasyntheticprogestogenthatexhibitscontraceptiveactivity,inhibitingsecretionoffollicle-stimulatinghormone(FSH)andluteinizinghormone(LH).Levonorgestrelisclinicallyusedinhormonalcontraceptivesandhormonereplacementtherapy.Invitro,levonorgestrelincreasesexpressionof17-βhydroxysteroiddehydrogenase.
| CasNo. | 797-63-7 |
|---|---|
| Purity | ≥98% |
| Formula | C21H28O2 |
| FormulaWt. | 312.45 |
| ChemicalName | 17-Ethynyl-18-methyl-19-nortestosterone |
| IUPACName | (8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one |
| Synonym | D(−)Norgestrel;Microlut;Microval;Norgeston;Norlevo;Norplant |
| MeltingPoint | 235-237°C |
| Solubility | Insolubleinwater.Slightlysolubleinalcohol. |
| Appearance | WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | L1684InfoSheetPDF |
|---|
Gemzell-DanielssonK,BergerC,PGLL.Emergencycontraception--mechanismsofaction.Contraception.2013Mar;87(3):300-8.PMID:23114735.
YuanP,ChenB,HuangY,etal.Long-termregressionofexperimentalendometriosisinaratmodeltreatedwithlocalapplicationoflevonorgestrel-loadedbiodegradablemicrospheres.HumReprod.2012Jul;27(7):2089-95.PMID:22563024.
SarkarNN.Theemergencycontraceptivedrug,levonorgestrel:areviewofpost-coitaloralandperi-coitalvaginaladmiNISTrationforpreventionofpregnancy.JObstetGynaecol.2011Nov;31(8):703-7.PMID:22085058.
