Medroxyprogesterone17-acetate(MPA)isasyntheticsteroidthatactivatesprogesterone,androgen,andglucocorticoidreceptors.MPAexhibitscontraceptiveandanticanceractivitiesandisalsousedinhormonereplacementtherapy,endometriosis,anddysmenorrhea.MPAdecreaseslevelsofadrenocorticotropichormone(ACTH),cortisol,andotherhormones;italsoinhibits3α-hydroxysteroiddehydrogenase.Thiscompoundisusedclinicallytotreatbreastcancerandinhibitstheproliferationandgrowthofbreastcancercellsandtumorsinvariousmodels.
| CasNo. | 71-58-9 |
|---|---|
| Purity | ≥98% |
| Formula | C24H34O4 |
| FormulaWt. | 386.52 |
| ChemicalName | 17-α-Acetoxy-6α-methylprogesterone |
| IUPACName | [(6S,8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]acetate |
| Synonym | MAP;Clinovir;Depo-Provera;Farlutal;Nidaxin;Oragest;Prodasone;Provera;Veramix |
| MeltingPoint | 207-209°C |
| Solubility | Solubleinchloroformoracetone. |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | M1613InfoSheetPDF |
|---|
SchindlerAE,CampagnoliC,DruckmannR,etal.Classificationandpharmacologyofprogestins.Maturitas.2008Sep-Oct;61(1-2):171-80.PMID:19434889.
MeyerL,VenardC,SchaefferV,etal.TheBIOLOGicalactivityof3alpha-hydroxysteroidoxido-reductaseinthespinalcordregulatesthermalandmechanicalpainthresholdsaftersciaticnerveinjury.NeurobiolDis.2008Apr;30(1):30-41.PMID:18291663.
PoulinR,BakerD,PoirierD,etal.Androgenandglucocorticoidreceptor-mediatedinhibitionofcellproliferationbymedroxyprogesteroneacetateinZR-75-1humanbreastcancercells.BreastCancerResTreat.1989Mar;13(2):161-72.PMID:2525057.
