Methotrexateisanantimetabolitethatexhibitsimmunosuppressive,abortifacient,anti-inflammatory,andanticancerchemotherapeuticactivities.Methotrexateisclinicallyusedtotreatvariouscancers,ectopicpregnancy,andrheumatoidarthritis.Methotrexateinhibitsdihydrofolatereductase,preventingthymidine,DNA,andRNAsynthesis.Invivo,methotrexateincreasesTcellapoptosis,decreasesTcellactivation,andsuppressescytokineproduction.
| CasNo. | 6745-93-3 |
|---|---|
| Purity | ≥98% |
| Formula | C20H22N8O5•H2O |
| FormulaWt. | 472.45 |
| ChemicalName | N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methyl-amino]benzoyl]-L-glutamicacid |
| IUPACName | (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioicacid |
| Synonym | L-(+)-AmethopterinDihydrate;Amethopterin;MTX;Emtexate;Ledertrexate;Rheumatrex |
| MeltingPoint | 185-204°C(dec.) |
| Solubility | Notsolubleinwaterorethanol.SolubleindiluteHClandinalkalinesoln. |
| Appearance | YellowCrystalPowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | M1676InfoSheetPDF |
|---|
HerfarthHH,LongMD,IsaacsKL.Methotrexate:underusedandignored?DigDis.2012;30Suppl3:112-8.doi:10.1159/000342735.PMID:23295701.
MolF,MolBW,AnkumWM,etal.Currentevidenceonsurgery,systemicmethotrexateandexpectantmanagementinthetreatmentoftubalectopicpregnancy:asystematicreviewandmeta-analysis.HumReprodUpdate.2008Jul-Aug;14(4):309-19.PMID:18522946.
WesselsJA,HuizingaTW,GuchelaarHJ.Recentinsightsinthepharmacologicalactionsofmethotrexateinthetreatmentofrheumatoidarthritis.Rheumatology(Oxford).2008Mar;47(3):249-55.PMID:18045808.
