Methylprednisoloneisasyntheticglucocorticoidthatdisplaysanti-inflammatoryandimmunosuppressiveactivities.Invitro,methylprednisolonedecreasessurvivalofactivatedCD4+Tcells.Inglioblastomacells,thiscompoundinhibitsoxidativestress-inducedapoptosis.Additionally,methylprednisolonedecreasesinfiltrationofimmunecellsandsuppressesreleaseofinflammatorycytokinesinanimalmodelsofinflammation.
| CasNo. | 83-43-2 |
|---|---|
| Purity | ≥96% |
| Formula | C22H30O5 |
| FormulaWt. | 374.47 |
| ChemicalName | (6α,11β)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione |
| IUPACName | (6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one |
| Synonym | Medrate;Medrol;Medrone;Urbason |
| MeltingPoint | 228-237°C |
| Solubility | Slightlysolubleinethanol(10mg/mL),dioxane,acetone,orchloroform.Insolubleinwater. |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | M1877InfoSheetPDF |
|---|
LuYS,PuLY,LiXC,etal.MethylprednisoloneinhibitsactivatedCD4+Tcellsurvivalpromotedbytoll-likereceptorligands.HepatobiliaryPancreatDisInt.2010Aug;9(4):376-83.PMID:20688601.
DasA,BanikNL,RaySK.MethylprednisoloneandindomethacininhibitoxidativestressmediatedapoptosisinratC6glioblastomacells.NeuRochemRes.2007Nov;32(11):1849-56.PMID:17570061.
SlokaJS,StefanelliM.Themechanismofactionofmethylprednisoloneinthetreatmentofmultiplesclerosis.MultScler.2005Aug;11(4):425-32.PMID:16042225.
