Epirubicinisananthracyclinethatexhibitsanticancerchemotherapeuticactivity;itisanisomerofdoxorubicin.EpirubicinactsasaDNAintercalatorandtopoisomeraseIIinhibitor,inhibitingDNAandRNAsynthesis.ThiscompoundalsoincreaseslevelsofROS.Epirubicinisclinicallyusedtotreatbreastcancer.
| CasNo. | 56390-09-1 |
|---|---|
| Purity | ≥90% |
| Formula | C27H29NO11•HCl |
| FormulaWt. | 579.99 |
| ChemicalName | 10-((3-amino-2,3,6-trideoxy-beta-L-arABIno-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-(8S-cis)-5,12-naphthacenedionehydrochloride |
| IUPACName | (7S,9S)-7-[(2R,4S,5R,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride |
| Synonym | 4"-Epiadriamycin;Epiadriamycin;Ridorubicin,Ellence,Farmorubicin,Pharmorubicin |
| MeltingPoint | 185°C(dec.) |
| Solubility | Solubleinwater,methanol.Insolubleinacetone |
| Appearance | Orange-redpowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | E6235MSDSPDF |
|---|---|
| InfoSheet | E6235InfoSheetPDF |
MonteiroLJ,KhongkowP,KongsemaM,etal.TheForkheadBoxM1proteinregulatesBRIP1expressionandDNAdamagerepairinepirubicintreatment.Oncogene.2013Sep26;32(39):4634-45.PMID:23108394.
ContePF,GennariA,LanducciE,etal.Roleofepirubicininadvancedbreastcancer.ClinBreastCancer.2000Sep;1Suppl1:S46-51.PMID:11970749.
