EPZ-6438isaninhibitorofEZH2,ahistonemethyltransferase(HMT)responsIBLeformethylationoflysineandarginineresiduesandcontrolsgenetranscriptionfidelityincells.EPZ-6438displaysanticancerchemotherapeuticactivityininvivomodelsbyinducingregressionofmalignantoratypicalteratoidrhaBDoidtumorscontainingalteredormutantSWI/SNFATP-dependentchromatinremodelers.
| CasNo. | 1403254-99-8 |
|---|---|
| Purity | ≥99% |
| Formula | C34H44N4O4 |
| FormulaWt. | 572.74 |
| IUPACName | N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-[4-(morpholin-4-ylmethyl)phenyl]benzamide |
| Synonym | E7438,Tazemetostat, |
| Solubility | InDMSO |
| Appearance | whitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | E6397InfoSheetPDF |
|---|---|
| Brochures | EpigeneticModifiersBooklet |
KnutsonSK,WarholicNM,WigleTJ,etal.DurabletumorregressioningeneticallyalteredmalignantrhabdoidtumorsbyinhibitionofmethyltransferaseEZH2.ProcNatlAcadSciUSA.2013May7;110(19):7922-7.PMID:23620515.
