Description
EsomeprazoleistheS-isomerofomeprazole,aprotonpumpinhibitor.EsomeprazoleinhibitsthegastricH+/K+ATPase,preventingH+secretion.Esomeprazoleisclinicallyusedtotreatulcersandgastroesophagealrefluxdisease(GERD).Esomeprazoleexhibitsanti-ulcerandanticancerchemotherapeuticactivities.Invitro,esomeprazoleinducesautophagybydecreasingmTORactivityandinducescaspase-dependentapoptosis,killingmelanomacells.Inanimalmodels,esomeprazoleincreasesgastricantioxidantcapacityandsuperoxidedismutase(SOD)activity,exhibitingsomeantioxidativebenefit.Esomeprazolealsoinducesapoptosisinosteoclastsandosteoblasts,potentiallydecreasingboneturnover.Additionally,thiscompoundinhibitsmonoamineoxidase(MAO-AandMAO-B).
References
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PetzerA,PienaarA,PetzerJP.Theinhibitionofmonoamineoxidasebyesomeprazole.DrugRes(Stuttg).2013Sep;63(9):462-7.PMID:23677700.
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