EstramustineisaderivativeofestrADIolandthenitrogenmustardmechlorethaminethatisclinicallyusedtotreatprostatecancer.Estramustineprimarilyexertsitsanticancerchemotherapeuticactivitythroughantimitoticactions.Estramustineacetylatesmicrotubules,stABIlizingthemandinducingdepolymerization,resultinginapoptosisacrossavarietyofcancercelltypes.EstramustinealsoincreasesDNAfragmentationingliomacellsandtumors(invivo),butnotinnormaltissue.
| CasNo. | 52205-73-9 |
|---|---|
| Purity | ≥95% |
| Formula | C23H30Cl2NO6PNa2 |
| FormulaWt. | 564.35 |
| IUPACName | disodium;[3-[bis(2-chloroethyl)carbamoyloxy]-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]phosphate |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | E7579MSDSPDF |
|---|---|
| InfoSheet | E7579InfoSheetPDF |
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