GDC-0449isaninhibitorofSmothatpreventsdownstreamhedgehog(Hh)signaling.GDC-0449exhibitsanticancerchemotherapeuticactivity;itiscurrentlyapprovedtotreatbasalcellcarcinomaandisinclinicaltrialsasapotentialtreatmentforothercancers.GDC-0449inhibitscellmotility,invasion,andcolonyformationinbasalcellcarcinomacells.
| CasNo. | 879085-55-9 |
|---|---|
| Purity | ≥98% |
| Formula | C19H14Cl2N2O3S |
| FormulaWt. | 421.30 |
| Synonym | GDC0449,Vismodegib |
| Appearance | WhiteCrystalPowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | G1408InfoSheetPDF |
|---|
IslamSS,MokhtariRB,NomanAS,etal.Sonichedgehog(Shh)signalingpromotestumOrigenicityandstemnessviaactivationofepithelial-to-mesenchymaltransition(EMT)inbladdercancer.MolCarcinog.2015Mar1.[Epubaheadofprint].PMID:25728352.
ErdemGU,SendurMA,OzdemirNY,etal.AcomprehensivereviewoftheroleofHedgehogpathwayandVismodegibinthemanagementofBasalCellCarcinoma.CurrMedResOpin.2015Feb17:1-45.PMID:25690490.
KimEJ,SahaiV,AbelEV,etal.PilotclinicaltrialofhedgehogpathwayinhibitorGDC-0449(vismodegib)incombinationwithgemcitABIneinpatientswithmetastaticpancreaticadenocarcinoma.ClinCancerRes.2014Dec1;20(23):5937-45.PMID:25278454.
