Mitotaneisananticancerchemotherapeuticcompoundclinicallyusedtotreatadrenocorticalcarcinoma,asittargetsonlyadrenalcellsandnotothers.Inadrenocorticalcells,mitotaneinhibitssecretionofcortisoland17-hydroxyprogesteroneanddecreasesactivityofcytochromecoxidase,suppressingmitochondrialrespirationandinhibitingcellproliferation.Mitotanemayinducehyperlipidemiainclinicalsubjects,asitincreasesserumlevelsofLDL,HDL,andtriglycerides.
| CasNo. | 53-19-0 |
|---|---|
| Purity | ≥98% |
| Formula | C14H10Cl4 |
| FormulaWt. | 320.04 |
| IUPACName | 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene |
| MeltingPoint | 76-78C |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | M3576InfoSheetPDF |
|---|
ShawaH,DenizF,BazerbashiH,etal.Mitotane-inducedhyperlipidemia:aretrospectivecohortstudy.IntJEndocrinol.2013;2013:624962.PMID:24348556.
HescotS,SlamaA,LombèsA,etal.Mitotanealtersmitochondrialrespiratorychainactivitybyinducingcytochromecoxidasedefectinhumanadrenocorticalcells.EndocrRelatCancer.2013May21;20(3):371-81.PMID:23696597.
FangVS.Cytotoxicactivityof1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane(mitotane)anditsanalogsonfeminizingadrenalneoplasticcellsinculture.CancerRes.1979Jan;39(1):139-45.PMID:761184.
