MonastrolisapyrimidinederivativeinhibitorofkinesinEg5thatinhibitsATPaseactivityandbipolarspindleformation.Monastrolexhibitsanticanceractivity,activatingthespindlecheckpointbutalsoinducingmitoticarrestandapoptosisinHeLacells.Monastrolalsoinducesdendritegrowthandaxonalshorteninginneurons.
| CasNo. | 254753-54-3 |
|---|---|
| Purity | ≥95% |
| Formula | C14H16N2O3S |
| FormulaWt. | 292.35 |
| ChemicalName | 1,2,3,4-Tetra-hydro-4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylicacidethylester |
| IUPACName | ethyl(4S)-4-(3-hydroxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate |
| MeltingPoint | 184-186°C(lit.) |
| Solubility | SolubleinDMSO(100mg/mL). |
| Appearance | Whitetolightyellowsolid |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | M5752InfoSheetPDF |
|---|
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MaligaZ,MitchisonTJ.Small-moleculeandmutationalanalysisofallostericEg5inhibitionbymonastrol.BMCChemBiol.2006Feb27;6:2.PMID:16504166.
YoonSY,ChoiJE,HuhJW,etal.Monastrol,aselectiveinhibitorofthemitotickinesinEg5,inducesadistinctivegrowthprofileofdendritesandaxonsinprimarycorticalneuroncultures.CellMotilCytoskeleton.2005Apr;60(4):181-90.PMID:15751098.
MaligaZ,KapoorTM,MitchisonTJ.EvidencethatmonastrolisanallostericinhibitorofthemitotickinesinEg5.ChemBiol.2002Sep;9(9):989-96.PMID:12323373.
