LKT/I-BET151/I0516/25 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/I-BET151/I0516/25 mg

LKT/I-BET151/I0516/25 mg

商品编号： I0516-25mg

品牌： lktlabs

市场价： ¥7340.00

美元价： 4404.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Product ID I0516

Cas No. 1300031-49-5

Purity ≥98%

Description
Product Info
Shipping and Storage
Downloads
References

Description

I-BET-151 is a BET bromodomain (BRD) inhibitor that inhibits BRD2, BRD3, and BRD4. I-BET-151 exhibits anticancer chemotherapeutic and anti-inflammatory activities. In vitro and in vivo, this compound induces apoptosis and inhibits cellular proliferation in various cancer models. I-BET-151 inhibits recruitment of the P-TEFb component of cyclin-dependent kinase 9 (CDK9) to chromatin, causing transcriptional regression of Myc. I-BET-151 also inhibits bacteria-induced inflammation and sepsis in animal models.

Product Info

Cas No.	1300031-49-5
Purity	≥98%
Formula	C₂₃H₂₁N₅O₃
Formula Wt.	415.44
IUPAC Name	7-(3,5-dimethyl-1,2-oxazol-4-yl)-8-methoxy-1-[(1R)-1-pyridin-2-ylethyl]-3H-imidazo[4,5-c]quinolin-2-one
Synonym	GSK-1210151A, GSK1210151A
Appearance	White to off white powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	I0516 MSDS PDF
Info Sheet	I0516 Info Sheet PDF

References

Chaidos A, Caputo V, Gouvedenou K, et al. Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762. Blood. 2014 Jan 30;123(5):697-705. PMID: 24335499.

Seal J, Lamotte Y, Donche F, et al. Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A). Bioorg Med Chem Lett. 2012 Apr 15;22(8):2968-72. PMID: 22437115.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂