Ibandronateisalongactingthirdgenerationbisphosphonatethatexhibitsanti-resorptive,anti-osteoporotic,andanti-angiogenicactivities.Ibandronateincreasesbonemineraldensity,decreasesresorption,andpreventsfracturesandpost-menopausalosteoporosis.Invitro,ibandronateincreasesproliferationofosteoblastsanddecreasesactivityofosteoclasts;itmayalsoinhibitangiogenesis.
| CasNo. | 138926-19-9 |
|---|---|
| Purity | ≥98% |
| Formula | C9H22NNaO7P2•H2O |
| FormulaWt. | 359.21 |
| ChemicalName | [1-Hydroxy-3-(methylpentylamino)propylidene]bis-phosphonicacid |
| IUPACName | sodium;hydroxy-[1-hydroxy-3-[methyl(pentyl)amino]-1-phosphonopropyl]phosphinate;hydrate |
| Synonym | Ibandronicacidsodiumsalt |
| MeltingPoint | 84°C(dec.) |
| Solubility | Solubleinwater. |
| Appearance | WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | I0502InfoSheetPDF |
|---|
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ZhouQ,ZhaoZN,ChengJT,etal.IbandronatepromotesosteogenicdifferentiationofperiodontalligamentstemcellsbyregulatingtheexpressionofmicroRNAs.BiochemBiophysResCommun.2011Jan7;404(1):127-32.PMID:21108928.
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