Ibandronate is a long acting third generation bisphosphonate that exhibits anti-resorptive, anti-osteoporotic, and anti-angiogenic activities. Ibandronate increases bone mineral density, decreases resorption, and prevents fractures and post-menopausal osteoporosis. In vitro, ibandronate increases proliferation of osteoblasts and decreases activity of osteoclasts; it may also inhibit angiogenesis.
| Cas No. | 138926-19-9 |
|---|---|
| Purity | ≥98% |
| Formula | C9H22NNaO7P2 • H2O |
| Formula Wt. | 359.21 |
| Chemical Name | [1-Hydroxy-3-(methylpentylamino)propylidene]bis- phosphonic acid |
| IUPAC Name | sodium;hydroxy-[1-hydroxy-3-[methyl(pentyl)amino]-1-phosphonopropyl]phosphinate;hydrate |
| Synonym | Ibandronic acid sodium salt |
| Melting Point | 84°C(dec.) |
| Solubility | Soluble in water. |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | I0502 Info Sheet PDF |
|---|
Ziebart T, Pabst A, Klein MO, et al. Bisphosphonates: restrictions for vasculogenesis and angiogenesis: inhibition of cell function of endothelial progenitor cells and mature endothelial cells in vitro. Clin Oral Investig. 2011 Feb;15(1):105-11. PMID: 20024592.
Zhou Q, Zhao ZN, Cheng JT, et al. Ibandronate promotes osteogenic differentiation of periodontal ligament stem cells by regulating the expression of microRNAs. Biochem Biophys Res Commun. 2011 Jan 7;404(1):127-32. PMID: 21108928.
Epstein S, Zaidi M. Biological properties and mechanism of action of ibandronate: application to the treatment of osteoporosis. Bone. 2005 Oct;37(4):433-40. PMID: 16046205.
