Ketotifenisasecond-generationantihistaminethatexhibitsanti-allergic,anti-asthma,anti-inflammatory,andimmunosuppressiveactivities.KetotifeninhibitsH1histaminereceptors,phosphodiesterases(PDEs),andleukotrienereceptors;italsoactsasamastcellstABIlizer.Inanimalmodelsofacutelunginjury,ketotifeninhibitsmastcellactivation,suppressesactivationofNF-κB,anddownregulatesexpressionofTNF-α,IL-1β,andIL-6.InanimalmodelsofTrichinellainfection,thiscompounddecreaseshumoralandcellularimmuneresponses.
| CasNo. | 34580-14-8 |
|---|---|
| Purity | ≥98% |
| Formula | C19H19NOS•C4H4O4 |
| FormulaWt. | 425.50 |
| ChemicalName | 4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-onefumarate |
| IUPACName | (E)-but-2-enedioicacid;10-(1-methylpiperidin-4-ylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one |
| Synonym | Allerkif;Totifen;ZADIten;Zasten |
| MeltingPoint | 192°C(dec.) |
| Solubility | Solubleinwater. |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | K1776InfoSheetPDF |
|---|
ZhangA,ChiX,LuoG,etal.Mastcellstabilizationalleviatesacutelunginjuryafterorthotopicautologouslivertransplantationinratsbydownregulatinginflammation.PLoSOne.2013Oct8;8(10):e75262.PMID:24116032.
DoligalskaM.EffectofketotifenontheimmuneresponseinBALB/cmiceinfectedwithTrichinellaspiralis.WiadParazytol.2000;46(2):217-24.PMID:16886340.
