GS-9973isanimidazopyrazineinhibitorofSykthatiscurrentlyinclinicaltrialsasapotentialtreatmentforchroniclymphocyticleukemia(CLL).GS-9973exhibitsanticancerchemotherapeuticactivity.Invitro,thiscompounddecreasessurvivalofCLLcells,inhibitscellgrowth,anddisruptschemokinesignaling.
| CasNo. | 1229208-44-9 |
|---|---|
| Purity | ≥98% |
| Formula | C23H21N7O |
| FormulaWt. | 411.46 |
| IUPACName | 6-(1H-Indazol-6-yl)-N-[4-(4-morpholinyl)phenyl]imidazo[1,2-a]pyrazin-8-amine |
| Synonym | GS9973,Entospletinib |
| Appearance | Yellowtooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | G7232InfoSheetPDF |
|---|
SharmanJ,HawkinsM,KolibabaK,etal.Anopen-labelphase2trialofentospletinib(GS-9973),aselectiveSykinhibitor,inchroniclymphocyticleukemia.Blood.2015Feb18.Epubaheadofprint].PMID:25696919.
CurrieKS,KropfJE,LeeT,etal.DiscoveryofGS-9973,aselectiveandorallyefficaciousinhibitorofspleentyrosinekinase.JMedChem.2014May8;57(9):3856-73.PMID:24779514.
BurkeRT,MeadowsS,LoriauxMM,etal.ApotentialtherapeuticstrategyforchroniclymphocyticleukemiabycombiningIdelalisibandGS-9973,anovelspleentyrosinekinase(Syk)inhibitor.Oncotarget.2014Feb28;5(4):908-15.PMID:24659719.
