GSK-1904529Aisaninhibitoroftheinsulinreceptor(InsR)andIGF-1Rthatexhibitsanticancerchemotherapeuticactivity.IncellularandanimalmodelsofmultiplemyelomaandEwing’ssarcoma,GSK-1904529Ainducescellcyclearrestandinhibitscellproliferationandtumorgrowth.
| CasNo. | 1089283-49-7 |
|---|---|
| Purity | ≥98% |
| Formula | C44H47F2N9O5S |
| FormulaWt. | 851.96 |
| IUPACName | N-(2,6-difluorophenyl)-5-[3-[2-[5-ethyl-2-methoxy-4-[4-(4-methylsulfonylpiperazin-1-yl)piperidin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]-2-methoxybenzamide |
| Synonym | GSK1904529A |
| Solubility | DMSO |
| Appearance | Yellowtopaleyellowpowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | G7541MSDSPDF |
|---|---|
| InfoSheet | G7541InfoSheetPDF |
SabbatiniP,RowandJL,GroyA,etal.AntitumoractivityofGSK1904529A,asmall-moleculeinhibitoroftheinsulin-likegrowthfactor-Ireceptortyrosinekinase.ClinCancerRes.2009May1;15(9):3058-67.PMID:19383820.
