GSK-690693isaninhibitorofAktthatdisplaysanticancerchemotherapeuticactivity.Inlungandcoloncancercells,GSK-690693inhibitscellgrowth.Inanimalmodelsofosteosarcoma,thiscompoundincreasessurvivalratesanddecreasestumorgrowth.Inothertransgenicanimalmodels,GSK-690693delayslungtumorformation,decreasescellproliferation,andinducesapoptosis.
| CasNo. | 937174-76-0 |
|---|---|
| Purity | ≥99% |
| Formula | C21H27N7O3 |
| FormulaWt. | 425.48 |
| IUPACName | 4-{2-(4-Amino-1,2,5-oxADIazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl}-2-methyl-3-butyn-2-ol |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | G7242InfoSheetPDF |
|---|
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CarolH,MortonCL,GorlickR,etal.Initialtesting(stage1)oftheAktinhibitorGSK690693bythepediatricpreclinicaltestingprogram.PediatrBloodCancer.2010Dec15;55(7):1329-37.PMID:20740623.
AltomareDA,ZhangL,DengJ,etal.GSK690693delaystumoronsetandprogressioningeneticallydefinedmousemodelsexpressingactivatedAkt.ClinCancerRes.2010Jan15;16(2):486-96.PMID:20075391.
