Heptaplatinisaplatinum-complexedanticancerchemotherapeuticcompoundapprovedinsomecountriesforthetreatmentofgastriccancers.Heptaplatinexhibitsanti-proliferativeactivityinmodelsofheadandnecksquamouscellcancerswhencombinedwith5-fluorouracil(5-FU)aswellasother,separatecancercelllines.
| CasNo. | 146665-77-2 |
|---|---|
| Purity | ≥98% |
| Formula | C11H20N2O6Pt |
| FormulaWt. | 471.36 |
| ChemicalName | [SP-4-2-[4R-(2a,4a,5b)]]-[2-(1-Methylethyl)-1,3-dioxolane-4,5-dimethanamine-N,N"][propanedioato(2-)-O,O"]-platinum |
| IUPACName | [(4R,5R)-5-(aminomethyl)-2-propan-2-yl-1,3-dioxolan-4-yl]methanamine;platinum;propanedioicacid |
| Synonym | Eptaplatin |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | H1862InfoSheetPDF |
|---|
LeeJW,ParkJK,LeeSH,etal.Anti-tumoractivityofheptaplatinincombinationwith5-fluorouracilorpaclitaxelagainsthumanheadandneckcancercellsinvitro.AnticancerDrugs.2006Apr;17(4):377-84.PMID:16549994.
KimNK,ImSA,KimDW,etal.PhaseIIclinicaltrialofSKI-2053R,anewplatinumanalog,inthetreatmentofpatientswithadvancedgastricadenocarcinoma.Cancer.1999Oct1;86(7):1109-15.PMID:10506693.
KimDK,KimHT,TaiJH,etal.Pharmacokineticsandantitumoractivityofanewplatinumcompound,cis-malonato[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane]platinum(II),asdeterminedbyexvivopharmacodynamics.CancerChemotherPharmacol.1995;37(1-2):1-6.PMID:7497577.
