Hexamethylenebisacetamide(HMBA)activateshexamethylenebisacetamide-inducIBLeprotein1(HEXIM1),inhibitingtranscriptionelongationfactorb(P-TEFb),aregulatorofRNApolymeraseIIandmRNAsynthesis.HMBAexhibitsanticanceractivityandisusedtoinducecellulardifferentiationandapoptosisincancercells.HMBAalsoinhibitsactivationofNF-κB,Akt,andERK.
| CasNo. | 3073-59-4 |
|---|---|
| Purity | ≥98% |
| Formula | C10H20N2O2 |
| FormulaWt. | 200.28 |
| ChemicalName | N,N"-Hexamethylene(bis)acetamide |
| IUPACName | N-(6-acetamidohexyl)acetamide |
| Synonym | N,N"-Diacetyl-1,6-hexanediamine;HMBA |
| MeltingPoint | 128-129°C |
| Solubility | Solubleinwaterorethanol. |
| Appearance | Whitecrystallinepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | H1892MSDSPDF |
|---|---|
| InfoSheet | H1892InfoSheetPDF |
LewQJ,ChiaYL,ChuKL,etal.IdentificationofHEXIM1asapositiveregulatorofp53.JBiolChem.2012Oct19;287(43):36443-54.PMID:22948151.
DeyA,WongE,KuaN,etal.Hexamethylenebisacetamide(HMBA)simultaneouslytargetsAKTandMAPKpathwayandrepressesNFkappaBactivity:implicationsforcancertherapy.CellCycle.2008Dec;7(23):3759-67.PMID:19029824.
ZhangZ,LiongEC,LauTY,etal.Inductionofapoptosisbyhexamethylenebisacetamideisp53-dependentassociatedwithtelomeraseactivitybutnotwithterminaldifferentiation.IntJOncol.2000May;16(5):887-92.PMID:10762623.
