LapatinibisaninhibitorofEGFR/HER2(ErbB2)thatiscurrentlyinclinicaltrialsasaco-admiNISTeredtreatmentwithotherchemotherapeutics.Lapatinibexhibitsanticancerchemotherapeuticbenefit,inducingapoptosisinbreastcancercells.Thiscompoundalsodownregulatesexpressionofthymidylatesynthaseinvitro.
| CasNo. | 388082-78-8 |
|---|---|
| Purity | ≥98% |
| Formula | C26H26ClFN4O4S2C7H8O3SH2O |
| FormulaWt. | 925.46 |
| IUPACName | N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine;4-methylbenzenesulfonicacid |
| MeltingPoint | 236-259°C |
| Solubility | SlightlyinDMSO |
| Appearance | Paleyellowtoyellowpowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | L0360MSDSPDF |
|---|---|
| InfoSheet | L0360InfoSheetPDF |
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KostyalD,WeltRS,DankoJ,etal.TrastuzumabandlapatinibmodulationofHER2tyrosine/threoninephosphorylationandcellsignaling.MedOncol.2012Sep;29(3):1486-94.PMID:21769502.
KimHP,YoonYK,KimJW,etal.Lapatinib,adualEGFRandHER2tyrosinekinaseinhibitor,downregulatesthymidylatesynthasebyinhibitingthenucleartranslocationofEGFRandHER2.PLoSOne.2009Jun16;4(6):e5933.PMID:19529774.
