JW55isaninhibitoroftankyrases(TNKS1/2)thatstABIlizestheβ-catenindegradationcomplex,suppressingWntsignaling.JW55displaysanti-obesityandpotentialanticanceractivities.Inanimalmodelsofhigh-fatdietanddiabetes,JW55decreasesbodyweightandintestinalepithelialstemcellproliferation.
| CasNo. | 664993-53-7 |
|---|---|
| Purity | ≥98% |
| Formula | C25H26N2O5 |
| FormulaWt. | 434.49 |
| IUPACName | N-[4-({[4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl]methyl}carbamoyl)phenyl]-2-furamide |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | J8800InfoSheetPDF |
|---|
MaoJ,HuX,XiaoY,etal.Overnutritionstimulatesintestinalepitheliumproliferationthroughβ-cateninsignalinginobesemice.Diabetes.2013Nov;62(11):3736-46.PMID:23884889.
WaalerJ,MachonO,TumovaL,etal.AnoveltankyraseinhibitordecreasescanonicalWntsignalingincoloncarcinomacellsandreducestumorgrowthinconditionalAPCmutantmice.CancerRes.2012Jun1;72(11):2822-32.PMID:22440753.
