Description
Kobe0065isaninhibitorofRasthatexhibitsanticancerchemotherapeuticactivities.Invitro,thiscompoundinhibitscellgrowthandinducesapoptosisandinvivo,itdecreasestumorgrowth.
Kobe0065isaninhibitorofRasthatexhibitsanticancerchemotherapeuticactivities.Invitro,thiscompoundinhibitscellgrowthandinducesapoptosisandinvivo,itdecreasestumorgrowth.
CasNo. | 436133-68-5 |
---|---|
Purity | ≥99% |
Formula | C15H11ClF3N5O4S |
FormulaWt. | 449.79 |
IUPACName | N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamide |
StoreTemp | -20°C |
---|---|
ShipTemp | Ambient |
InfoSheet | K5604InfoSheetPDF |
---|
ShimaF,YoshikawaY,YeM,etal.Insilicodiscoveryofsmall-moleculeRasinhibitorsthatdisplayantitumoractivitybyblockingtheRas-effectorinteraction.ProcNatlAcadSciUSA.2013May14;110(20):8182-7.PMID:23630290.
ShimaF,YoshikawaY,MatsumotoS,etal.Discoveryofsmall-moleculeRasinhibitorsthatdisplayantitumoractivitybyinterferingwithRas·GTP-effectorinteraction.Enzymes.2013;34Pt.B:1-23.PMID:25034098.