Description
Kobe0065isaninhibitorofRasthatexhibitsanticancerchemotherapeuticactivities.Invitro,thiscompoundinhibitscellgrowthandinducesapoptosisandinvivo,itdecreasestumorgrowth.
Kobe0065isaninhibitorofRasthatexhibitsanticancerchemotherapeuticactivities.Invitro,thiscompoundinhibitscellgrowthandinducesapoptosisandinvivo,itdecreasestumorgrowth.
| CasNo. | 436133-68-5 |
|---|---|
| Purity | ≥99% |
| Formula | C15H11ClF3N5O4S |
| FormulaWt. | 449.79 |
| IUPACName | N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamide |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | K5604InfoSheetPDF |
|---|
ShimaF,YoshikawaY,YeM,etal.Insilicodiscoveryofsmall-moleculeRasinhibitorsthatdisplayantitumoractivitybyblockingtheRas-effectorinteraction.ProcNatlAcadSciUSA.2013May14;110(20):8182-7.PMID:23630290.
ShimaF,YoshikawaY,MatsumotoS,etal.Discoveryofsmall-moleculeRasinhibitorsthatdisplayantitumoractivitybyinterferingwithRas·GTP-effectorinteraction.Enzymes.2013;34Pt.B:1-23.PMID:25034098.