KPT-330isaCRM1-selectiveinhibitorofnuclearexport(SINE)thatinhibitsproteintraffickingfromthenucleus.KPT-330displaysanticancerchemotherapeuticactivity.Inmesotheliomacells,thiscompoundinhibitscellgrowthandinducesG1phasecellcyclearrestandapoptosis;invivo,itsuppressestumorgrowth.
| CasNo. | 1421923-86-5 |
|---|---|
| Purity | ≥99% |
| Formula | C17H11F6N7O |
| FormulaWt. | 443.31 |
| IUPACName | (2Z)-3-{3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-N"-(2-pyrazinyl)acrylohydrazide |
| Synonym | Selinexor |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | K6276InfoSheetPDF |
|---|
IshizawaJ,KojimaK,HailNJr,etal.Expression,function,andtargetingofthenuclearexporterchromosomeregionmaintenance1(CRM1)protein.PharmacolTher.2015Jun3.[Epubaheadofprint].PMID:26048327.
DeCesareM,CominettiD,DoldiV,etal.Anti-tumoractivityofselectiveinhibitorsofXPO1/CRM1-mediatednuclearexportindiffusemalignantperitonealmesothelioma:theroleofsurvivin.Oncotarget.2015May30;6(15):13119-32.PMID:25948791.
ParikhK,CangS,SekhriA,etal.Selectiveinhibitorsofnuclearexport(SINE)--anovelclassofanti-canceragents.JHematolOncol.2014Oct15;7:78.PMID:25316614.
