Idarubicin is an anthracycline and daunorubicin analog that exhibits anticancer chemotherapeutic activity; it is clinically used to treat leukemias. Idarubicin intercalates DNA, inhibiting topoisomerase II and inducing double-stranded DNA breaks and causing histone eviction.
| Cas No. | 57852-57-0 |
|---|---|
| Purity | ≥98% |
| Formula | C26H27NO9 • HCl |
| Formula Wt. | 533.96 |
| Chemical Name | (7S,9S)-9-Acetyl-7-[(3-amino-2,3,6-trideoxy-α-L- lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11- trihydroxy-5,12-naphthacenedione hydrochloride |
| IUPAC Name | (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride |
| Synonym | Idamycin; Zavedos |
| Melting Point | 183-185°C |
| Solubility | Soluble in water and methanol. |
| Appearance | Orange-red powder; odorless |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | I1400 Info Sheet PDF |
|---|
Eda Satana Kara H. Redox mechanism of anticancer drug idarubicin and in-situ evaluation of interaction with DNA using an electrochemical biosensor. Bioelectrochemistry. 2014 Oct;99:17-23. PMID: 24967755.
Pang B, Qiao X, Janssen L, et al. Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin. Nat Commun. 2013;4:1908. PMID: 23715267.
Crivellari D, Lombardi D, Spazzapan S, et al. New oral drugs in older patients: a review of idarubicin in elderly patients. Crit Rev Oncol Hematol. 2004 Feb;49(2):153-63. PMID: 15012975.
