InauhzinisaninhibitorofSIRT1thatactivatesp53;italsoinhibitsinosinemonophosphatedehydrogenase(IMPDH).Inauhzinexhibitsanticancerchemotherapeuticactivities,inducingapoptosisandsuppressingcellgrowthinnon-smallcelllungcancer(NSCLC)andcoloncancercells.Thiscompoundalsoinducessenescenceinandrepressestumorgrowthincellularandanimalmodelsoflungcancerandcoloncarcinoma.
| CasNo. | 309271-94-1 |
|---|---|
| Purity | ≥98% |
| Formula | C25H19N5OS2 |
| FormulaWt. | 469.58 |
| IUPACName | 1-(10H-Phenothiazin-10-yl)-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)-1-butanone |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | I5203InfoSheetPDF |
|---|
ZhangQ,ZhouX,WuR,etal.TheroleofIMPdehydrogenase2inInauhzin-inducedribosomalstress.Elife.2014Oct27;3.PMID:25347121.
ZhangY,ZhangQ,ZengSX,etal.Inauhzinsensitizesp53-dependentcytotoxicityandtumorsuppressionofchemotherapeuticagents.Neoplasia.2013May;15(5):523-34.PMID:23633924.
