- Description
- Product Info
- Shipping and Storage
- Downloads
- References
Description
Enfuvirtide is a synthetic peptide derived from HIV-1 that exhibits antiviral activity. Enfuvirtide inhibits viral fusion, mimicking the amino acid sequence of gp41, preventing fusion of the virus to the host cell membrane. Enfuvirtide may also induce apoptosis in bystander cells.
Product Info
159519-65-0 |
≥95% |
C204H301N51O64 |
4462.0 |
T20; Fuzeon; Pentafuside; DP178. |
Enfuvirtide lyophilized powder is best dissolved in alkaline conditions such as sterile pyrogen free 0.1% NaOH, 1% Na2CO3 or disodium phenyl phosphate at a concentration of 0.1mg/ml-1mg/ml. Enfuvirtide is insoluble in water. |
White to off white powder |
Shipping and Storage
-20°C |
Ambient |
Downloads
E5220 MSDS PDF |
E5220 Info Sheet PDF |
References
Tan JJ, Ma XT, Liu C, et al. The current status and challenges in the development of fusion inhibitors as therapeutics for HIV-1 infection. Curr Pharm Des. 2013;19(10):1810-7. PMID: 23092283.
Cai L, Gochin M, Liu K. Biochemistry and biophysics of HIV-1 gp41 - membrane interactions and implications for HIV-1 envelope protein mediated viral-cell fusion and fusion inhibitor design. Curr Top Med Chem. 2011 Dec;11(24):2959-84. PMID: 22044229.
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